Methyl iodide → HCID 11587625, compound

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Reaction Steps

The title compound was prepared from (3,4-dimethoxy-phenyl)-(2-methyl-quinazolin-4-yl)-amine (288 mg, 0.98 mmol), methyl iodide (0.094 ml, 1.47 mmol), sodium hydride (60 mg, 1.5 mmol) in DMF similar to example 21 to give 70 mg (23%) of off white solids. 1H NMR (CDCl3): 7.75-7.72 (m, 1H), 7.56-7.50 (m, 1H), 7.05-6.94 (m, 2H), 6.85 (d, J=7.5 Hz, 1H), 6.76-6.71 (m, 2H), 3.92 (s, 3H)), 3.78 (s, 3H), 3.61 (s, 3H), 2.73 (s, 3H).

Provenance & Evidence