Methyl chloroformate → HCID 11508604, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (6-amino-2-methyl-quinazolin-4-yl)-(4-methoxy-phenyl)-methylamine (150 mg, 0.51 mmol) in 5 ml of THF was added potassium carbonate (160 mg, 1.16 mmol), 2 mg of sodium sulfate. The reaction mixture was cooled to 0° C., and methyl chloroformate (0.4 ml, 5 mmol) was added. The reaction mixture was stirred at 0° C. for 10-15 min, then diluted with EtOAc (20 ml), washed with water, brine, dried over Na2SO4, filtered and concentrated by vacuum. The crude product was purified by chromatography on silica gel with acetate, hexane (1:3 to 1:1) as eluent, yielding 129 mg of title compound (72%) as yellow solids. 1H NMR (CDCl3): 7.70 (s, 2H), 7.12-7.07 (m, 2H), 6.94-6.89 (m, 3H), 6.32 (brs, 1H), 3.84 (s, 3H), 3.70 (s, 3H), 3.57 (s, 3H), 2.70 (s, 3H).

Provenance & Evidence