Sodium Hydroxide → HCID 59362896, compound

Participants

Reaction Conditions

Reaction Steps

A solution of sodium hydroxide (4.14 g, 100 mmol) in water (100 mL) was added to a solution of 1-[4-(2-cyclopentyl-6,7-dihydro-5H-cyclopentapyrimidin-4-ylamino)-phenyl]-cyclopentanecarboxylic acid methyl ester (7.0 g, 17.2 mmol) in MeOH (100 mL) and the mixture was heated at 90° C. for 8 hours. After evaporation of MeOH under reduced pressure, the mixture was cooled to a temperature in the range of 15° C. to 40° C., and acidified with hydrochloric acid to adjust pH to 3-4. The precipitate formed after standing at a temperature in the range of 15° C. to 40° C. was filtered and washed several times with water, and dried under vacuum. The solid was recrystallized from MeOH to afford the title compound as a white powder (6.3 g, 94% yield).

Provenance & Evidence