Tert-Butylamine → tert-butyl-(2-chloro-6,7-dihydro-5H-cyclopentapyrimidin-4-yl)-amine

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Reaction Steps

A mixture of 2,4-dichloro-6,7-dihydro-5H-cyclopentapyrimidine (0.47 g, 2.5 mmol), tert-butylamine (1.25 ml, 11.8 mmol) and isopropanol (5 ml) was heated at reflux for 8 to 18 hours. After evaporation of volatiles the mixture was purified by flash chromatography over silica gel to afford the title compound as a white solid (0.36 g, 64% yield).

Provenance & Evidence