Lithium → HCID 59362904, compound

Participants

Reaction Steps

Lithium aluminumhydride (2M solution in tetrahydrofuran, 1.5 mL) was added drop-wise to a solution of 1-[4-(2-morpholin-4-yl-6,7-dihydro-5H-cyclopentapyrimidin-4-ylamino)-phenyl]-cyclobutanecarboxylic acid (0.61 g, 1.52 mmol) in anhydrous tetrahydrofuran (10 mL) at 0° C. to 5° C. After addition, the reaction mixture was warmed to a temperature in the range of 15° C. to 40° C. and stirring continued for an additional 10 hours. The reaction was quenched by addition of aqueous sodium hydroxide. The precipitated solid was filtered and washed with ethyl acetate. The combined filtrates were washed with brine, dried over Na2SO4, filtered, and concentrated to yield a white solid. The title compound was afforded following purification by column chromatography (silica gel) as a white solid (0.56 g, 80% yield).

Provenance & Evidence