4-(Pyrrolidine-1-sulfonyl)aniline → HCID 59362894, compound

Participants

Reaction Steps

1-[4-(2-chloro-6,7-dihydro-5H-cyclopentapyrimidin-4-ylamino)-phenyl]cyclobutanecarboxylic acid methyl ester (0.36 g, 1 mmol) was added to a solution of 4-(pyrrolidine-1-sulfonyl)-phenylamine (0.24 g, 1.06 mmol) in anhydrous isopropanol (10 mL) and the mixture was stirred at a temperature in the range of 60° C. to 110° C. for 40 to 50 hours. The reaction was cooled to a temperature in the range of 15° C. to 25° C. The precipitated solid was filtered, washed with ether, and dried in vacuo to afford the title compound as a white solid (0.28 g, 54% yield).

Provenance & Evidence