Formaldehyde → HCID 178480929, compound

HRID 16689Notes

Reaction equation

HRID 16689 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]([C:11]2[O:19][C:18]3[C:13](=[N:14][CH:15]=[CH:16][CH:17]=3)[C:12]=2[NH:20][C:21]([C@H:23]2[CH2:28][CH2:27][C@H:26]([N:29]3[CH2:34][CH2:33][NH:32][CH2:31][C:30]3=[O:35])[CH2:25][CH2:24]2)=[O:22])=[O:10])=[N:6][CH:7]=1.[CH2:36]=O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]([C:11]2[O:19][C:18]3[C:13](=[N:14][CH:15]=[CH:16][CH:17]=3)[C:12]=2[NH:20][C:21]([C@H:23]2[CH2:28][CH2:27][C@H:26]([N:29]3[CH2:34][CH2:33][N:32]([CH3:36])[CH2:31][C:30]3=[O:35])[CH2:25][CH2:24]2)=[O:22])=[O:10])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 712FormaldehydeHCID 178522101HCID 178522101, compound

Product 1

HCID 178480929HCID 178480929, compound

Procedure

N-(5-Chloropyridin-2-yl)-3-({[trans-4-(2-oxopiperazin-1-yl)cyclohexyl]carbonyl}amino)furo[3,2-b]pyridine-2-carboxamide (60 mg) obtained in Example 125 and 35% aqueous formaldehyde solution (19 μl) are treated in a similar manner to Example 120 to give the title compound (46 mg).

Sources & evidence

ORD record
ord-3061064ac1304ca0a5f282fb2824ce8c
Source dataset
uspto-grants-2010_06
Patent number
US07737161B2

Reaction notes

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