Isopropanol → N-(2,3-dihydro-1H-inden-5-yl)-8-iodo-7-methylquinazolin-4-amine hydrochloride

Participants

Role	Name	HCID	Charge
Reactant	Isopropanol	HCID 3776	—
Reactant	Indan-5-amine	HCID 90496	—
Reactant	4-Chloro-8-iodo-7-methylquinazoline	HCID 58466484	—
Solvent	Ethyl Acetate	HCID 8857	—
Product	N-(2,3-dihydro-1H-inden-5-yl)-8-iodo-7-methylquinazolin-4-amine hydrochloride	HCID 67338686	87%

Reaction Conditions

Temperature	110 °C

Reaction Steps

2,3-Dihydro-1H-inden-5-amine (109 mg, 821 μmol), 4-chloro-8-iodo-7-methylquinazoline (250 mg, 821 μmol) and IPA (5 mL) were added to microwave-vial. The reaction mixture was heated at 110° C. for 10 min. A precipitate formed upon cooling. The crude product was diluted with EtOAc (20 mL), filtered, washed twice with EtOAc (20 mL) and air-dried to give N-(2,3-dihydro-1H-inden-5-yl)-8-iodo-7-methylquinazolin-4-amine hydrochloride (311 mg, 87%) as an amorphous off-white solid. MS (M+H)+ 402.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07989461B2
Source dataset	uspto-grants-2011_08
ORD ID	ord-8f110ed7139f4f41b4cef882103f96be
Source note	uspto-grants-2011_08