反应详情

N,N-Dimethyl-1,2-ethanediamine (0.28 mL, 2.5 mmol) was added to a stirred solution of chloride 5 (187 mg, 0.8 mmol) in DME (30 mL), and the solution stirred at reflux temperature for 2 h. The solvent was evaporated and the residue was partitioned between DCM (100 mL) and dilute aqueous NH3 solution (50 mL). The organic fraction was dried and the solvent evaporated. The residue was purified by chromatography, eluting with a gradient (0-10%) of MeOH/DCM, to give 1-oxide 6 (201 mg, 88%) as a pale yellow solid: mp (MeOH/EtOAc) 186-190° C.; 1H NMR δ 7.54 (d, J=8.4 Hz, 1H, H-6), 7.37 (d, J=8.4 Hz, 1H, H-5), 5.80 (br s, 1H, NH), 3.63 (br t, J=7.3 Hz, 2H, H-9), 3.52-3.57 (m, 2H, CH2N), 2.96 (br t, J=7 Hz, 2H, H-7), 2.57 (t, J=6.0 Hz, 2H, CH2N), 2.29 [s, 6H, N(CH3)2], 2.12-2.21 (m, 2H, H-8); 13C NMR δ 158.5, 149.0, 142.0, 137.3, 132.2, 129.2, 124.7, 57.6, 45.0 (2), 38.7, 35.3, 32.9, 24.8. Anal. calcd for C14H19N5O.¼H2O: C, 60.5; H, 7.1; N, 25.2. Found: C, 60.6; H, 6.6; N, 25.4%.

1. temperatureat reflux temperature for 2 h
2. customThe solvent was evaporated
3. customthe residue was partitioned between DCM (100 mL) and dilute aqueous NH3 solution (50 mL)
4. customThe organic fraction was dried
5. customthe solvent evaporated
6. customThe residue was purified by chromatography
7. washeluting with a gradient (0-10%) of MeOH/DCM