Acetyl chloride → HCID 178473910, compound

HRID 16690Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]([C:11]2[O:19][C:18]3[C:13](=[N:14][CH:15]=[CH:16][CH:17]=3)[C:12]=2[NH:20][C:21]([C@H:23]2[CH2:28][CH2:27][C@H:26]([N:29]3[CH2:34][CH2:33][NH:32][CH2:31][C:30]3=[O:35])[CH2:25][CH2:24]2)=[O:22])=[O:10])=[N:6][CH:7]=1.[C:36](Cl)(=[O:38])[CH3:37]>>[C:36]([N:32]1[CH2:33][CH2:34][N:29]([C@H:26]2[CH2:27][CH2:28][C@H:23]([C:21]([NH:20][C:12]3[C:13]4=[N:14][CH:15]=[CH:16][CH:17]=[C:18]4[O:19][C:11]=3[C:9]([NH:8][C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][N:6]=3)=[O:10])=[O:22])[CH2:24][CH2:25]2)[C:30](=[O:35])[CH2:31]1)(=[O:38])[CH3:37]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 178522101HCID 178522101, compound

Product 1

HCID 178473910HCID 178473910, compound

Procedure

N-(5-Chloropyridin-2-yl)-3-({[trans-4-(2-oxopiperazin-1-yl)cyclohexyl]carbonyl}amino)furo[3,2-b]pyridine-2-carboxamide (50 mg) obtained in Example 125 and acetyl chloride (9 μl) are treated in a similar manner to Example 122 to give the title compound (41 mg).

Sources & evidence

ORD record: ord-6524847bf8834e8994a6c4db3b0dec77
Source dataset: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07737161B2

Reaction notes

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