N,N-Diethylethylenediamine → HCID 11950762, compound

Participants

Reaction Steps

N1,N1-Diethyl-1,2-ethanediamine (0.50 mL, 3.5 mmol) was added to a stirred solution of chloride 21 (314 mg, 1.4 mmol) in DME (50 mL) and the solution stirred at reflux temperature for 2 h. The solvent was evaporated and the residue partitioned between DCM (100 mL) and dilute aqueous NH3 solution (50 mL). The organic fraction was dried and the solvent evaporated. The residue was purified by chromatography, eluting with a gradient (0-10%) of MeOH/DCM, to give 1-oxide 26 (406 mg, 95%) as a yellow solid: mp (MeOH/EtOAc) 109-112° C.; 1H NMR δ 7.93 (s, 1H, H-9), 7.31 (s, 1H, H-5), 7.14 (br s, 1H, NH), 3.97-4.03 (m, 2H, CH2N), 3.42-3.46 (m, 2H, CH2N), 3.25-3.33 (m, 4H, 2×CH2N), 2.19-2.29 (m, 4H, H-6, H-8), 2.08-2.14 (m, 2H, H-7), 1.45 (t, J=7.3 Hz, 6H, 2×CH3); 13C NMR δ 158.2, 154.6, 148.4, 143.7, 129.8, 120.7, 114.4, 50.8, 47.7 (2), 36.3, 33.1, 32.3, 25.7, 8.8 (2). Anal. calcd for C16H23N5O: C, 63.8; H, 7.7; N, 23.2. Found: C, 63.9; H, 7.7; N, 23.3%.

Provenance & Evidence