Ethylamine → HCID 11952366, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of bromide 125 (91 mg, 0.31 mmol), 70% ethylamine (0.5 mL) and DME (3 mL) was stirred at 20° C. for 3 h. The mixture was partitioned between EtOAc and aqueous Na2CO3 solution. The organic layer was separated, dried and the solvent evaporated to give compound 126 (74 mg, 92%) as yellow solid: mp (EtOAc) 150° C.; 1H NMR δ 8.07 (s, 1H, H-9), 7.40 (s, 1H, H-5), 5.07 (br s, 1H, NH), 3.64-3.72 (m, 2H, CH2O), 3.50-3.58 (m, 2H, CH2N), 3.11-3.21 (m, 2H, CH2), 2.71-2.93 (m, 3H, CH2, CH), 1.29 (t, J=7.2 Hz, 3H, CH3), OH not observed; HRMS calcd for C13H16N4O2 (M+) m/z 260.1271, found 260.1273.

Provenance & Evidence