Ammonia → HCID 19261833, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of nitroacetamide 167 (151 mg, 0.65 mmol) in 6 M HCl (30 mL) was stirred at 100° C. for 6 h. The suspension was cooled to 20° C., diluted with water (50 mL) and the pH adjusted to 8 with aqueous NH3 solution. The mixture was extracted with DCM (3×50 mL), the combined organic fraction dried, and the solvent evaporated to give amine 174 (113 mg, 100%) as an orange solid: 1H NMR δ 7.83 (s, 1H, H-4), 7.50 (s, 1H, H-1), 5.79 (s, 2H, NH2), 2.67-2.73 (m, 4H, 2×CH2), 1.78-1.83 (m, 4H, 2×CH2).

Provenance & Evidence