N,N-Dimethylethylenediamine → HCID 25140757, compound

Participants

Reaction Steps

N,N-Dimethyl-1,2-ethanediamine (0.23 mL, 2.1 mmol) was added to a stirred solution of chloride 187 (178 mg, 0.7 mmol) in DME (30 mL) and the solution stirred at reflux temperature for 2 h. The solvent was evaporated and the residue partitioned between DCM (100 mL) and dilute aqueous NH3 solution (50 mL). The organic fraction was dried and the solvent evaporated. The residue was purified by chromatography, eluting with a gradient (0-10%) of MeOH/DCM, to give 1-oxide 188 (204 mg, 95%) as a yellow solid: mp (MeOH) 149-152° C.; 1H NMR δ 7.96 (s, 1H, H-11), 7.31 (s, 1H, H-5), 5.84 (br s, 1H, NH), 3.52-3.57 (m, 2H, CH2N), 2.85-2.90 (m, 4H, H-6, H-10), 2.58 (br t, J=6.0 Hz, 2H, CH2N), 2.28 [s, 6H, N(CH3)2], 1.79-1.85 (m, 2H, H-8), 1.65-1.74 (m, 4H, H-7, H-9); 13C NMR δ 159.0, 153.4, 148.0, 142.1, 129.0, 125.0, 118.8, 57.6, 45.1 (2), 38.7, 36.8, 36.2, 32.0, 28.7, 28.4. Anal. calcd for C16H23N5O.½H2O: C, 61.9; H, 7.8; N, 22.6. Found: C, 62.0; H, 7.8; N, 22.4%.

Provenance & Evidence