(4-Methoxy-1-piperidinyl)acetonitrile → 2-(4-Methoxy-piperidin-1-yl)-ethylamine

Participants

Reaction Steps

A mixture of nitrile 287 (10.25 g, 66.5 mmol) and Raney Nickel (50% w/w in water, ca. 10 mL) in EtOH (150 mL) and cNH3 (10 mL) was stirred under H2 (60 psi) for 16 h. The mixture was filtered through Celite, washed with EtOH (3×10 mL) and the solvent evaporated to give crude diamine 288 as an oil which was used directly.

Provenance & Evidence