Potassium Carbonate → HCID 57447695, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 2-methoxy-N-methylethanamine (266) (20.0 g, 224 mmol), N-(3-bromopropyl)phthalimide (50.1 g, 187 mmol) and K2CO3 (31.0 g, 224 mmol) in DMF (200 mL) was stirred at 100° C. for 3 h. The solution was cooled and the solvent evaporated to give phthalimide 298 (51.7 g, 100%) as a colourless oil, which was used without further purification: 1H NMR δ 7.82-7.86 (m, 2H, Harom), 7.68-7.73 (m, 2H, Harom), 3.73 (t, J=7.2 Hz, 2H, CH2N), 3.42-3.46 (m, 2H, CH2O), 3.32 (s, 3H, OCH3), 2.53-2.56 (m, 2H, CH2N), 2.44-2.49 (m, 2H, CH2N), 2.25 (s, 3H, NCH3), 1.82-1.90 (m, 2H, CH2); HRMS (Cl+) calcd for C15H21N2O3 (MH+) m/z 277.1552, found 277.1557.

Provenance & Evidence