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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1669223Generated: November 5, 2026

3-(4-Benzyloxy-benzoylamino)-propionic acid methyl ester → 3-(4-Hydroxy-benzoylamino)-propionic acid methyl ester

https://huagongshe.com/reaction/1669223

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(4-Benzyloxy-benzoylamino)-propionic acid methyl esterHCID 26635368—
CatalystPalladium hydroxideHCID 9942167—
SolventMethanolHCID 887—
Product3-(4-Hydroxy-benzoylamino)-propionic acid methyl esterHCID 10632853—

Reaction Conditions

Temperature40 °C

Reaction Steps

A mixture of 3-(4-benzyloxy-benzoylamino)-propionic acid methyl ester (11.26 g, 35.93 mmol) and Pd(OH)2/C (20%, 3.19 g) in MeOH was heated at 40° C. for 12 h. The mixture was filtered through celite to yield 7.89 (98%) of the title compound. The following compound was made in a similar manner:

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07989457B2
Source datasetuspto-grants-2011_08
ORD IDord-4028aead678a4a908c8d9f043528f55b
Source noteuspto-grants-2011_08