HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(4-(Trifluoromethyl)phenyl)nicotinaldehyde → (6-(4-(Trifluoromethyl)phenyl)pyridin-3-yl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(4-(Trifluoromethyl)phenyl)nicotinaldehyde | HCID 21936449 | — |
| Reactant | HCID 178461630 | HCID 178461630 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (6-(4-(Trifluoromethyl)phenyl)pyridin-3-yl)methanol | HCID 21935952 | — |
| Product | 1-[6-(4-Trifluoromethyl-phenyl)-pyridin-3-yl]-propan-1-ol | HCID 59729419 | — |
Reaction Steps
To a solution of 6-(4-trifluoromethyl-phenyl)-pyridine-3-carbaldehyde (2.1 g, 8.3 mmol) in THF (20 mL) is added EtMgBr (3.0 M in Et2O, 3.2 mL, 9.6 mmol) at 0˜5° C., stirred for 2 hrs, quenched by NH4Cl aq., extracted with ethyl acetate, dried and concentrated giving 1-[6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-propan-1-ol (1.8 g) and [6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-methanol (0.29 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07989457B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-71d643e386a049fb8c7a40f6aefe9a6e |
| Source note | uspto-grants-2011_08 |