Hydrochloric Acid → HCID 86620353, compound

Participants

Reaction Steps

A solution of 4-(1-methoxymethylenepropyl)-4′-trifluoromethylbiphenyl (278 mg, 0.908 mmol) in THF (9.1 mL) is treated with concentrated hydrochloric acid (0.456 mL), and the reaction is heated at reflux overnight. The reaction mixture is cooled to RT, and extracted with EtOAc (3×). The combined organic layers are dried and concentrated, giving 2-(4′-trifluoromethylbiphenyl-4-yl)butyraldehyde as a crude residue to be used as is (weight in excess of theoretical yield).

Provenance & Evidence