HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Dimethyl-4'-trifluoromethyl-biphenyl-4-carbaldehyde → 1-(2,6-Dimethyl-4'-trifluoromethyl-biphenyl-4-yl)-3-methyl-butan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Dimethyl-4'-trifluoromethyl-biphenyl-4-carbaldehyde | HCID 86085306 | — |
| Reactant | HCID 178418816 | HCID 178418816 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(2,6-Dimethyl-4'-trifluoromethyl-biphenyl-4-yl)-3-methyl-butan-1-ol | HCID 59729393 | — |
Reaction Steps
To a solution of 2,6-Dimethyl-4′-trifluoromethyl-biphenyl-4-carbaldehyde (1.0 g, 3.6 mmol) in THF (10 mL) at 0° C. is added isobutyl magnesium bromide (2M, 2.2 mL). After stirring at room temperature for 2 hours, it is quenched with saturated ammonium chloride, extracted with EtOAc. The organic is concentrated to give the titled compound as colorless oil: 0.47 g (39%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07989457B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-5cc1586d5cd340888c45c2627adfa660 |
| Source note | uspto-grants-2011_08 |