Sodium Hydroxide → HCID 11512058, compound

HRID 1669261Notes

Reaction equation

HRID 1669261 reaction equation
C[O:2][C:3](=[O:39])[CH2:4][CH2:5][NH:6][C:7](=[O:38])[C:8]1[CH:13]=[CH:12][C:11]([O:14][C@H:15]([C:22]2[CH:23]=[N:24][C:25]([C:28]3[CH:33]=[CH:32][C:31]([C:34]([F:37])([F:36])[F:35])=[CH:30][CH:29]=3)=[CH:26][CH:27]=2)[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])=[CH:10][CH:9]=1.[OH-].[Na+]>C(O)C>[F:36][C:34]([F:35])([F:37])[C:31]1[CH:30]=[CH:29][C:28]([C:25]2[N:24]=[CH:23][C:22]([C@@H:15]([O:14][C:11]3[CH:12]=[CH:13][C:8]([C:7]([NH:6][CH2:5][CH2:4][C:3]([OH:39])=[O:2])=[O:38])=[CH:9][CH:10]=3)[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])=[CH:27][CH:26]=2)=[CH:33][CH:32]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 67342716HCID 67342716, compound

Product 1

HCID 11512058HCID 11512058, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

or (S)-3-(4-{1-[6-(4-Trifluoromethyl-phenyl)-pyridin-3-yl]-heptyloxy}-benzoylamino)-propionic acid methyl ester is taken into ethanol (2 mL), treated with 5N NaOH (1 mL) for 2 h, concentrated, acidified with 5 N HCl, extracted with ethyl acetate, dried over sodium sulfate. Concentration gives (R) or (S)-3-(4-{1-[6-(4-Trifluoromethyl-phenyl)-pyridin-3-yl]-heptyloxy}-benzoylamino)-propionic acid.

Workup

  1. concentrationconcentrated
  2. extractionextracted with ethyl acetate
  3. dry with materialdried over sodium sulfate
  4. concentrationConcentration

Sources & evidence

ORD record
ord-b59b0a765d684010967e44f6e2c504f9
Source dataset
uspto-grants-2011_08
Patent number
US07989457B2

Reaction notes

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