HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1669263Generated: October 30, 2026
Hydrochloric Acid → 3-[4-(3-Methyl-4'-trifluoromethyl-biphenyl-4-ylmethoxy)-benzoylamino]-propionic acid
https://huagongshe.com/reaction/1669263
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-[4-(3-Methyl-4'-trifluoromethyl-biphenyl-4-ylmethoxy)-benzoylamino]-propionic acid methyl ester | HCID 67343502 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-[4-(3-Methyl-4'-trifluoromethyl-biphenyl-4-ylmethoxy)-benzoylamino]-propionic acid | HCID 11583375 | — |
Reaction Steps
A mixture of 3-[4-(3-methyl-4′-trifluoromethyl-biphenyl-4-ylmethoxy)-benzoylamino]-propionic acid methyl ester (0.11 g) and 5M NaOH (1.5 mL) in THF (3 mL) is heated to 70° C. for 12 h. The mixture is acidified with 5M HCl, and extracted with EtOAc. The organics are washed with water and brine, and dried with MgSO4 to yield the title compound. MS (ES): 458 (M+). The structure is also confirmed by 1H NMR.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07989457B2 |
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| Source dataset | uspto-grants-2011_08 |
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| ORD ID | ord-606a4a837e8641bb8413e0c83a56d6e4 |
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| Source note | uspto-grants-2011_08 |
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