Hydrochloric Acid → HCID 11703791, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-[4-(3-methyl-biphenyl-4-ylmethoxy)-benzoylamino]-propionic acid methyl ester (0.17 g, 0.42 mmol) and 5M NaOH (2 mL) in THF (4 mL) is heated at 70° C. for 5 h. The mixture is acidified with 5M HCl, and extracted with EtOAc. The organics are washed with water and brine, and dried with MgSO4 to yield the title compound (42 mg, 26%). MS (ES): 390 (M+). The structure is also confirmed by 1H NMR.

Provenance & Evidence