Sodium borohydride → HCID 67342731, compound

Participants

Reaction Conditions

Reaction Steps

1-[2-(4-Trifluoromethyl-phenyl)-pyrimidin-5-yl]-heptan-1-one (1.47 g, 4.36 mmol) is dissolved in ethanol and cooled to 0° C. while stirring under nitrogen. To the flask is added sodium borohydride (165 mg, 4.36 mmol), and the reaction is kept at 0° C. for 1 h., then slowly warmed to room temperature. The reaction is monitored by HPLC. Upon complete consumption of starting material, the reaction is carefully quenched with water, the ethanol removed by rotary evaporator, and extracted with diethyl ether, washed, dried, and concentrated. The title compound is used in the next step without further purification.

Provenance & Evidence