反应详情

温度

0 °C

To an ethanol (2 mL) solution of 1-(4′-trifluoromethyl-biphenyl-4-yl)-butan-2-one (0.093 g, 0.32 mmol) is added sodium borohydride (0.048 g, 1.27 mmol) at 0° C. The reaction mixture is stirred one hour at 0° C., quenched by saturated sodium bicarbonate solution (1 mL) and stirred for five minutes, extracted with ethyl acetate. Organic phase is washed with saturated sodium bicarbonate and brine dried over sodium sulfate, filtered and concentrated to give 0.088 g (0.30 mmol, 94%) of title compound.

1. customquenched by saturated sodium bicarbonate solution (1 mL)
2. stirringstirred for five minutes
3. extractionextracted with ethyl acetate
4. washOrganic phase is washed with saturated sodium bicarbonate and brine
5. dry with materialdried over sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated