Hydrochloric Acid → 4-[1-(4'-Trifluoromethyl-biphenyl-4-ylmethyl)-propoxy]-benzoic acid

Participants

Reaction Steps

To a solution of 4-[1-(4′-trifluoromethyl-biphenyl-4-ylmethyl)-propoxy]-benzoic acid methyl ester (0.048 g, 0.11 mmol) in ethanol (3 mL) is added sodium hydroxide (5.0N, 0.11 mL, 0.54 mmol) and stirred for four hours, acidified with 1.0 N HCl and extracted ethyl acetate three times. Organic layers are dried with sodium sulfate, filtered and concentrated under reduced pressure to provide 0.04 g (0.1 mmol, 89%) of title compound.

Provenance & Evidence