Hydrochloric Acid → HCID 59729415, compound

Participants

Reaction Conditions

Reaction Steps

2-Chloro-5-(1-methoxymethylene-heptyl)-pyridine is dissolved into anhydrous tetrahydrofuran (20 mL) and concentrated hydrochloric acid (2 mL) are added with stirring under nitrogen. The reaction is heated to 50° C. and monitored by HPLC. Upon complete consumption of starting material, the reaction is carefully neutralized with sodium hydroxide, extracted with diethyl ether, washed, dried, and concentrated. The 2-(6-Chloro-pyridin-3-yl)-octanal (1.02 g, 4.26 mmol), 32% two steps, is obtained in purified form after flash column chromatography.

Provenance & Evidence