Sodium Hydroxide → HCID 67343466, compound

Participants

Reaction Steps

To a mixture of 3-{4-[1-(4′-trifluoromethyl-biphenyl-4-yl)-hept-1-enyl]-benzoylamino}-propionic acid methyl ester (40 mg) in methanol (2 mL) is added sodium hydroxide (5 N aqueous, 0.5 mL) and stirred for 5 h. The reaction mixture is concentrated and acidified by 5 NHCl (0.5 mL), extracted with ethyl acetate. Combined organic layers are washed with water and brine, dried over sodium sulfate. Concentration gives the title compound (30 mg). MS (ES): 508.3 [M+H]−.

Provenance & Evidence