Bromine → HCID 67341888, compound

HRID 1669318Notes

Reaction equation

HRID 1669318 reaction equation
[CH3:1][O:2][C:3](=[O:20])[C:4]1[CH:9]=[CH:8][C:7]([C:10](=[O:19])[C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=2)=[CH:6][CH:5]=1.[Br:21]Br>ClCCl>[CH3:1][O:2][C:3](=[O:20])[C:4]1[CH:5]=[CH:6][C:7]([C:10](=[O:19])[C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([Br:21])[CH:12]=2)=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 257913Benzoic acid, 4-(4-methoxybenzoyl)-, methyl ester

Product 1

HCID 67341888HCID 67341888, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To the solution of 4-(4-methoxy-benzoyl)-benzoic acid methyl ester (3.4 g, 12.6 mmol) in dichloromethane (10 mL) is added bromine (2.4 g, 15.1 mmol). The solution is stirred at room temperature till the starting material is gone. Then the mixture is diluted with dichlormethane, washed with 1N NaOH, water, brine, dried, and purified with column chromatography to give the titled compound as a yellow solid: 4.42 g (100%).

Workup

  1. washwashed with 1N NaOH, water, brine
  2. customdried
  3. custompurified with column chromatography

Sources & evidence

ORD record
ord-d058eba41105477eb056abcb79db7df7
Source dataset
uspto-grants-2011_08
Patent number
US07989457B2

Reaction notes

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