反应详情

To the solution of 4-(4-methoxy-benzoyl)-benzoic acid methyl ester (3.4 g, 12.6 mmol) in dichloromethane (10 mL) is added bromine (2.4 g, 15.1 mmol). The solution is stirred at room temperature till the starting material is gone. Then the mixture is diluted with dichlormethane, washed with 1N NaOH, water, brine, dried, and purified with column chromatography to give the titled compound as a yellow solid: 4.42 g (100%).

1. washwashed with 1N NaOH, water, brine
2. customdried
3. custompurified with column chromatography