HCID 67341665, compound → HCID 67341927, compound

Participants

Reaction Steps

To a solution of 3-{4-[1-(6-methoxy-4′-trifluoromethyl-biphenyl-3-yl)-hept-1-enyl]-benzoylamino}-propionic acid methyl ester (330 mg) in ethanol (10 mL) is added Pd/C (5%, 20 mg). The system is purged with N2, filled with H2 (30 PSI), stirred at room temperature for 5 h. Then the mixture is filtered through celites, and the filtrate is concentrated to give 3-{4-[1-(6-methoxy-4′-trifluoromethyl-biphenyl-3-yl)-heptyl]-benzoylamino}-propionic acid methyl ester (290 mg), hydrolyze by 5N NaOH (0.5 mL) to afford the titled compound. MS (ES): 540.3 [M+H]−.

Provenance & Evidence