Sodium Hydroxide → 3-(3-Fluoro-4-{1-[6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-heptyloxy}-benzoylamino)-propionic acid

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Reaction Steps

Add sodium hydroxide (5.0N, 0.07 mL, 0.34 mmol) to 3-(3-fluoro-4-{1-[6-(4-trifluoromethyl-phenyl)-pyridin-3-yl]-heptyloxy}-benzoylamino)-propionic acid methyl ester (0.038 g, 0.07 mmol) in methanol (0.5 mL) and stir for three hours. Acidify with 1.0 N HCl and extract desired compound with ethyl acetate three times. Dry organic fractions with Na2SO4, filter and concentrate under reduced pressure to provide 0.025 g (66%) of title compound. MS (ESI) m/z 547.2 (M++H).

Provenance & Evidence