反应详情

温度

0 °C

1-(4-Bromo-3-methyl-phenyl)-5-methyl-hexan-1-one (3.5 g, 12.4 mmol) was dissolved in ethanol and cooled to 0° C. while stirring under nitrogen. To the flask was added sodium borohydride (469 mg, 12.4 mmol), and the reaction was kept at 0° C. for 1 h., then slowly warmed to room temperature. The reaction was monitored by HPLC. Upon complete consumption of starting material, the reaction is carefully quenched with water, the ethanol removed by rotary evaporator, and extracted with diethyl ether, washed, dried, and concentrated. The title compound (3.33 g, 11.72 mmol), is used in the next step without further purification.

1. temperatureslowly warmed to room temperature
2. customUpon complete consumption of starting material
3. customthe reaction is carefully quenched with water
4. customthe ethanol removed by rotary evaporator
5. extractionextracted with diethyl ether
6. washwashed
7. customdried
8. concentrationconcentrated