Sodium Hydroxide → 3-{3-Fluoro-4-[1-(4'-trifluoromethyl-biphenyl-4-yl)-heptyloxy]-benzoylamino}-propionic acid

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Reaction Steps

Add sodium hydroxide (5.0N, 0.03 mL, 0.15 mmol) to 3-{3-fluoro-4-[1-(4′-trifluoromethyl-biphenyl-4-yl)-heptyloxy]-benzoylamino}-propionic acid ethyl ester (0.0172 g, 0.03 mmol) in ethanol (0.5 mL) and stir for three hours. Acidify with 1.0 N HCl and extract desired compound with ethyl acetate three times. Dry organic fractions with Na2SO4, filter and concentrate under reduced pressure to provide 0.015 g (92%) of title compound. MS (ESI) m/z 546.3 [M+H]+.

Provenance & Evidence