反应详情

Add sodium hydroxide (5.0N, 0.03 mL, 0.15 mmol) to 2-methyl-4′-trifluoromethyl-biphenyl-4-carboxylic acid methyl ester (2.52 g, 8.6 mmol) in methanol (15 mL) and stir for two hours. Acidify with 1.0 N HCl and extract desired compound with ethyl acetate three times. Wash organic phase with saturated sodium chloride solution, dry over Na2SO4, filter and concentrate under reduced pressure to provide 2.31 g (96%) of title compound.

1. extractionAcidify with 1.0 N HCl and extract desired compound with ethyl acetate three times
2. dry with materialWash organic phase with saturated sodium chloride solution, dry over Na2SO4
3. filtrationfilter
4. concentrationconcentrate under reduced pressure