HRID1669342

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14798

Sodium Hydroxide

HNaO

结构：CCCCCCC(Oc1ccc(C(=O)NCCC(=O)OCC)cc1F)c1ccc(-c2ccc(C(F)(F)F)cc2)c(C)c1

HCID59729408

未命名化合物

PRODUCTS

生成物

结构：CCCCCCC(Oc1ccc(C(=O)NCCC(=O)O)cc1F)c1ccc(-c2ccc(C(F)(F)F)cc2)c(C)c1

HCID59729382

未命名化合物

收率 83%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

Add sodium hydroxide (5.0N, 0.03 mL, 0.15 mmol) to 3-{3-Fluoro-4-[1-(2-methyl-4′-trifluoromethyl-biphenyl-4-yl)-heptyloxy]-benzoylamino}-propionic acid ethyl ester (0.024 g, 0.041 mmol) in ethanol (5 mL) and stir for three hours. Acidify with 1.0 N HCl and extract desired compound with ethyl acetate three times. Wash organic phase with saturated sodium chloride solution, dry over Na2SO4, filter, and concentrate under reduced pressure to provide 0.019 g (83%) of title compound. MS (ESI) m/z 560.2 [M+H]+.

WORKUP

后处理

extractionAcidify with 1.0 N HCl and extract desired compound with ethyl acetate three times
dry with materialWash organic phase with saturated sodium chloride solution, dry over Na2SO4
filtrationfilter
concentrationconcentrate under reduced pressure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d29c8c1677c741b69a20b1b3a7964524
来源数据集: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07989457B2
来源说明: uspto-grants-2011_08

反应 SMILES

[OH-].[Na+].C([O:5][C:6](=[O:44])[CH2:7][CH2:8][NH:9][C:10](=[O:43])[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH:18]([C:25]2[CH:30]=[CH:29][C:28]([C:31]3[CH:36]=[CH:35][C:34]([C:37]([F:40])([F:39])[F:38])=[CH:33][CH:32]=3)=[C:27]([CH3:41])[CH:26]=2)[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])=[C:13]([F:42])[CH:12]=1)C>C(O)C>[F:42][C:13]1[CH:12]=[C:11]([CH:16]=[CH:15][C:14]=1[O:17][CH:18]([C:25]1[CH:30]=[CH:29][C:28]([C:31]2[CH:36]=[CH:35][C:34]([C:37]([F:38])([F:39])[F:40])=[CH:33][CH:32]=2)=[C:27]([CH3:41])[CH:26]=1)[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[C:10]([NH:9][CH2:8][CH2:7][C:6]([OH:44])=[O:5])=[O:43]