Ethylene Glycol → HCID 23131804, compound

HRID 1669348Notes

Reaction equation

HRID 1669348 reaction equation
Br[CH2:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH:6]=[O:7].[OH-].[Na+].[CH2:13]([OH:16])[CH2:14][OH:15]>O>[OH:15][CH2:14][CH2:13][O:16][CH2:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[CH:6]=[O:7]

Participants

5

Reactant 3

HCID 174Ethylene GlycolHCID 14798Sodium HydroxideHCID 71278253-(Bromomethyl)benzaldehyde

Product 1

HCID 23131804HCID 23131804, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
55 °C

Procedure

A mixture of 1.99 g of 3-(bromomethyl)benzaldehyde, 0.80 g of sodium hydroxide and 8 ml of ethylene glycol was heated at 55° C. for 6 hours. After water was added, the mixture was extracted with chloroform and then washed with an aqueous saturated sodium chloride solution. After dried over anhydrous sodium sulfate and then concentration under reduced pressure, the resulting residue was subjected to silica gel column chromatography to obtain 0.79 g of oily 3-[(2-hydroxyethoxy)methyl]benzaldehyde [Compound No. (g)].

Workup

  1. extractionthe mixture was extracted with chloroform
  2. washwashed with an aqueous saturated sodium chloride solution
  3. dry with materialAfter dried over anhydrous sodium sulfate
  4. concentrationconcentration under reduced pressure

Sources & evidence

ORD record
ord-70b1b70cb5604257ab267a2bfe009e78
Source dataset
uspto-grants-2011_08
Patent number
US07989478B2

Reaction notes

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