Triphenylphosphine → HCID 136337340, compound

Participants

Reaction Steps

To a mixture of 200 mg of 4-hydroxy-3-[3-(3-hydroxyphenyl)-1-oxo-2-propenyl]-1,6-dimethyl-2(1H)-pyridinone, 10 ml of tetrahydrofuran, 170 mg of N-(t-butoxycarbonyl)-2-aminoethanol and 276 mg of triphenylphosphine was added dropwise 414 μl of diethyl azodicarboxylate (40% toluene solution), and this was stirred at room temperature for 47 hours. The solvent was distilled off under reduced pressure, and the resulting residue was subjected to silica gel column chromatography to obtain 75 mg of 4-hydroxy-3-[3-[3-[N-(t-butoxycarbonyl)-2-aminoethoxy]phenyl]-1-oxo-2-propenyl]-1,6-dimethyl-2(1H)-pyridinone [Compound No. (54a)].

Provenance & Evidence