Dimethyl Sulfate → HCID 67346107, compound

HRID 1669376Notes

Reaction equation

[OH:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]([CH3:9])[C:4](=[O:10])[C:3]=1[C:11](=[O:25])[CH:12]=[CH:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH2:21][C:22]([NH2:24])=[O:23])[CH:15]=1.S(OC)(O[CH3:30])(=O)=O>>[CH3:30][O:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]([CH3:9])[C:4](=[O:10])[C:3]=1[C:11](=[O:25])[CH:12]=[CH:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH2:21][C:22]([NH2:24])=[O:23])[CH:15]=1

Participants

Reactant 2

HCID 6497Dimethyl Sulfate

HCID 136344255HCID 136344255, compound

Product 1

HCID 67346107HCID 67346107, compound

Procedure

According to the same manner as that of Example a-25 except that 0.78 g of 4-hydroxy-3-[3-[3-(aminocarbonylmethoxy)phenyl]-1-oxo-2-propenyl]-1,6-dimethyl-2(1H)-pyridinone was used in place of 4-hydroxy-3-[3-[3-(2-hydroxyethoxy)phenyl]-1-oxo-2-propenyl]-1,6-dimethyl-2(1H)-pyridinone, and 0.5 ml of dimethyl sulfate was used in place of iodomethane, 0.18 g of 4-methoxy-3-[3-[3-(aminocarbonylmethoxy)phenyl]-1-oxo-2-propenyl]-1,6-dimethyl-2(1H)-pyridinone [Compound No. (68a)] was obtained as a yellow crystal.

Sources & evidence

ORD record: ord-14f2fb16e1b24d4bb5086e9d8caddd27
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07989478B2

Reaction notes

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