Hexamethylphosphoramide → HCID 67345649, compound

HRID 1669378Notes

Reaction equation

[OH:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]([CH3:9])[C:4](=[O:10])[C:3]=1[C:11](=[O:28])[CH:12]=[CH:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([NH:22][CH2:23][C:24]([O:26][CH3:27])=[O:25])=[O:21])[CH:15]=1.[CH3:29]N(C)P(N(C)C)(N(C)C)=O>>[CH3:29][O:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]([CH3:9])[C:4](=[O:10])[C:3]=1[C:11](=[O:28])[CH:12]=[CH:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([NH:22][CH2:23][C:24]([O:26][CH3:27])=[O:25])=[O:21])[CH:15]=1

Participants

Reactant 2

HCID 12679Hexamethylphosphoramide

HCID 136344258HCID 136344258, compound

Product 1

HCID 67345649HCID 67345649, compound

Procedure

According to the same manner as that of Example a-25 except that 0.25 g of 4-hydroxy-3-[3-[3-[(methoxycarbonylmethyl)aminocarbonyl]phenyl]-1-oxo-2-propenyl]-1,6-dimethyl-2(1H)-pyridinone was used in place of 4-hydroxy-3-[3-[3-(2-hydroxyethoxy)phenyl]-1-oxo-2-propenyl]-1,6-dimethyl-2(1H)-pyridinone, and 6 ml of hexamethylphosphoramide was used in place of dimethylformamide, 0.13 g of 4-methoxy-3-[3-[3-[(methoxycarbonylmethyl)aminocarbonyl]phenyl]-1-oxo-2-propenyl]-1,6-dimethyl-2(1H)-pyridinone [Compound No. (83a)] was obtained as a pale yellow crystal.

Sources & evidence

ORD record: ord-198d27e3e4af4ed69a84eddc924892c7
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07989478B2

Reaction notes

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