Methyl iodide → HCID 137227882, compound

Participants

Reaction Steps

To a solution of 0.40 g of 4-hydroxy-3-[3-[(3-methylthioureido)phenyl]-1-oxo-2-propenyl]-1,6-dimethyl-2(1H)-pyridinone in 7 ml of dimethylformamide was added 0.044 g of sodium hydride (60% oily) at room temperature, and this was stirred for 1 hour. 0.26 g of iodomethane was added thereto, and this was stirred at room temperature overnight. The solvent was distilled off under reduced pressure, and the residue was purified by column chromatography to obtain 0.079 g of yellow oily 4-hydroxy-3-[3-[(2,3-dimethylisothioureido)phenyl]-1-oxo-2-propenyl]-1,6-dimethyl-2(1H)-pyridinone [Compound No. (115a)].

Provenance & Evidence