Bromoacetonitrile → HCID 136344267, compound

Participants

Reaction Steps

To a solution of 0.50 g of 4-hydroxy-3-[3-[3-(cyanomethoxy)phenyl]-1-oxo-2-propenyl]-6-methyl-2(1H)-pyridinone in 6 ml of hexamethylphosphoramide was added 46 mg of sodium hydride (60% oily) under ice-cooling, and this was stirred at room temperature for 1 hour. To the reaction mixture was added 0.33 ml of bromoacetonitrile under ice-cooling, and this was stirred at room temperature for 2 hours. The solvent was distilled off under reduced pressure, and precipitated crystals were filtered, washed with t-butyl methyl ether, and dried to obtain 0.14 g of 1-(cyanomethoxy)-3-[3-[3-(cyanomethoxy)phenyl]-1-oxo-2-propenyl]-4-hydroxy-6-methyl-2(1H)-pyridinone [Compound No. (6c)] as a yellow crystal.

Provenance & Evidence