反应详情

温度

60 °C

2N NaOH (aq) (6 eq) was added to a solution of methyl (7R)-7-[{2-[(tert-butoxycarbonyl)amino]ethyl}(methyl)amino]-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate (0.02 M) in MeOH/THF (3/1) and the reaction stirred vigorously at 60° C. for 4 h. The reaction was allowed to cool to RT before reducing the volume of MeOH/THF in vacuo. The residue was partitioned between 1N HCl (aq) and EtOAc, ensuring the aqueous phase was acidic. The aqueous was extracted a second time with EtOAc and the combined organics washed with water, brine before being dried (Na2SO4), filtered and concentrated in vacuo. The material was taken on without further purification. MS (ES+) m/z 548 (M+H)+.

1. temperatureto cool to RT
2. customThe residue was partitioned between 1N HCl (aq) and EtOAc
3. extractionThe aqueous was extracted a second time with EtOAc
4. washthe combined organics washed with water, brine
5. dry with materialbefore being dried (Na2SO4)
6. filtrationfiltered
7. concentrationconcentrated in vacuo
8. customThe material was taken on without further purification