HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1669408Generated: October 31, 2026
Water → (7S)-14-cyclohexyl-7-[2-(methylamino)ethoxy]-N-{[methyl(2-oxoethyl)amino]sulfonyl}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxamide
https://huagongshe.com/reaction/1669408
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (7S)-14-cyclohexyl-N-{[(2,2-dimethoxyethyl)(methyl)amino]sulfonyl}-7-[2-(methylamino)ethoxy]-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxamide | HCID 67345577 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (7S)-14-cyclohexyl-7-[2-(methylamino)ethoxy]-N-{[methyl(2-oxoethyl)amino]sulfonyl}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxamide | HCID 86627893 | — |
Reaction Steps
A solution of (7S)-14-cyclohexyl-N-{[(2,2-dimethoxyethyl)(methyl)amino]sulfonyl}-7-[2-(methylamino)ethoxy]-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxamide (0.06 M) in DCM was treated with an excess of TFA and H2O (>50 eq). The mixture was stirred at 40° C. for 30 min. All the volatiles were concentrated in vacuo to give the title compound, which was taken on without further purification. (ES+) m/z 583 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07989438B2 |
|---|
| Source dataset | uspto-grants-2011_08 |
|---|
| ORD ID | ord-c340688c50964058aa5e7e97494bfbbf |
|---|
| Source note | uspto-grants-2011_08 |
|---|
