Hydrochloric Acid → HCID 67344694, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 3-cyclohexyl-2-[2-(methoxymethoxy)-4-(pyridin-2-ylmethoxy)phenyl]-1H-indole-6-carboxylate was dissolved in MeOH (0.5 M). 3N HCl (2 eq) was added, followed by more MeOH. The mixture was warmed to 80° C. for 6 h. By this time a clear solution had formed. All volatiles were evaporated in vacuo and the residual material was dissolved in DCM. The solution was washed with sat. aq. NaHCO3 and brine. After drying over Na2SO4 all volatiles were evaporated in vacuo leaving a beige amorphous solid (quant). (ES+) m/z 457 (M+H)+.

Provenance & Evidence