Cesium carbonate → HCID 67343119, compound

Participants

Reaction Steps

Methyl 3-cyclohexyl-2-[2-[(2S)-oxiran-2-ylmethoxy]-4-(pyridin-2-ylmethoxy)phenyl]-1H-indole-6-carboxylate was dissolved in DMF (0.1 M) and the solution was added slowly to a suspension of Cs2CO3 (0.5 eq) in DMF at 65° C. After 1 h the mixture was diluted with Et2O. The solution was extracted with H2O, sat. aq. NaHCO3 and brine. After drying over Na2SO4 all volatiles were evaporated in vacuo to leave an orange amorphous solid. The product was purified by FC (PE:EtOAc, 1:1+1% NEt3 to wash away remaining starting material, then EtOAc:MeOH, 9:1+1% NEt3). The product was obtained as a yellowish amorphous solid (62%). (ES+) m/z 513 (M+H)+.

Provenance & Evidence