tert-butyl {2-[[(7R)-14-cyclohexyl-11-[({[(2,2-dimethoxyethyl)(methyl)amino]-sulfonyl}amino)carbonyl]-3-(pyridin-2-ylmethoxy)-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocin-7-yl](methyl)amino]ethyl}methylcarbamate → (7R)-14-cyclohexyl-7-{methyl[2-(methylamino)ethyl]amino}-N-{[methyl(2-oxoethyl)amino]sulfonyl}-3-(pyridin-2-ylmethoxy)-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxamide

Participants

Reaction Conditions

Reaction Steps

tert-butyl {2-[[(7R)-14-cyclohexyl-11-[({[(2,2-dimethoxyethyl)(methyl)amino]-sulfonyl}amino)carbonyl]-3-(pyridin-2-ylmethoxy)-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocin-7-yl](methyl)amino]ethyl}methylcarbamate was dissolved in DCM/H2O/TFA (8:1:3, 15 mM). The mixture was warmed to 40° C. After 30 min all volatiles were evaporated in vacuo and the residual material was coevaporated twice with toluene. The remaining yellow oil was used in the next reaction without further purification.

Provenance & Evidence