Hydrochloric Acid → 6-{2-[(tert-butoxycarbonyl)(methyl)amino]ethyl}-13-cyclohexyl-3-methoxy-6,7-dihydro-5H-indolo[2,1-a][2]benzazepine-10-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

To a 0.05M solution of methyl 6-{2-[(tert-butoxycarbonyl)(methyl)amino]ethyl}-13-cyclohexyl-3-methoxy-6,7-dihydro-5H-indolo[2,1-a][2]benzazepine-10-carboxylate in dioxane, 1M aqueous KOH solution (10 eq) was added and the mixture was heated to 70° C. After 2 h the mixture was neutralised with 1N HCl and then all volatiles were removed in vacuo. The residue was taken up with DCM and filtered to remove salts. The crude material was used without purification in the next step. (ES+) m/z 547 (M+H)+.

Provenance & Evidence