HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-((1,1-dimethylethoxy)carbonyl)-beta-alanine → HCID 67346526, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-((1,1-dimethylethoxy)carbonyl)-beta-alanine | HCID 76809 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 66675025 | HCID 66675025 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 67346526 | HCID 67346526 | — |
Reaction Steps
A solution of methyl 7(R,S)-(2-aminoethyl)-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate (0.14 M) in DCM was treated with N-(tert-butoxycarbonyl)-β-alanine (2 eq) followed by HATU (1.3 eq) and DIPEA (2.5 eq) and the resulting mixture was stirred overnight at RT. The reaction was diluted with EtOAc and the combined organic layers were washed with sat. aq. NaHCO3, HCl (1N) and brine, before being dried (Na2SO4), filtered and concentrated in vacuo. The product was used directly in the next step without further purification. (ES+) m/z 604 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07989438B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-9b63b56d0e6c49daaf6bfd307c9bcc6d |
| Source note | uspto-grants-2011_08 |