Trifluoroacetic acid → HCID 67346293, compound

Participants

Reaction Steps

A solution of methyl 7(R,S)-{2-[[N-(tert-butoxycarbonyl)-N-methyl-β-alanyl](methyl)amino]ethyl}-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate (0.09 M) in DCM was treated with TFA (20 eq) and the resulting mixture was stirred overnight at RT. The reaction was diluted with EtOAc and the combined organic layers were washed with sat. aq. NaHCO3 then brine, before being dried (Na2SO4), filtered and concentrated in vacuo. The product was used directly in the next step without further purification. (ES+) m/z 532 (M+H)+.

Provenance & Evidence