Potassium Hydroxide → HCID 67345302, compound

Participants

Reaction Conditions

Reaction Steps

A solution of methyl (7R)-7-[(2-{3-[{[(tert-butoxycarbonyl)amino]sulfonyl}(methyl)amino]pyrrolidin-1-yl}ethyl)(methyl)amino]-14-cyclohexyl-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylate in dioxane was treated with aqueous KOH (1M) (3 eq) and heated at 70° C. for 1 h. The residue obtained after evaporation of all volatiles was taken into EtOAc, acidified with HCl (1N), and the organics washed with brine, dried and concentrated in vacuo to get the title compound as a white powder. (ES+) m/z 710 (M+H)+.

Provenance & Evidence